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I. V. t-PA for Acute Ischemic Stroke, Feasibility, Safety & Efficacy in the First Year of Clinical Practice Stroke 29:18-22, Chiu,D.,et al, 1998 See this aricle in Pubmed Article Abstract Six percent(6%)of all patients hospitalized with ischemic stroke received intravenous t-PA at the university hospital and 1.1%at the community hospitals.The rates of total,symptomatic,and fatal intracerebral hemorrhage were 10%,7%,and 3%.Thirty-seven percent(37%)of patients recovered to fully independent function.The average time from stroke onset to emergency department arrival was 57 minutes;emergency department arrival to computed tomography scan 41 minutes;and computed tomography scan to administration of treatment 59 minutes.When treatment guidelines are carefully followed in an urban hospital setting,intravenous t-PA for acute ischemic stroke is feasible and shows safety and efficacy comparable to the results of the NINDS study.

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